Endometriosis and intestinal disorders may have a genetic link – scientists
[ad_1]
Scientists have discovered a genetic link between endometriosis and several digestive disorders, including irritable bowel syndrome (IBS).
This is according to a study published in the journal Cell Reports Medicine, Live Science reports.
To find the link between endometriosis and bowel disease, the study authors first looked at data from 188,461 women in the UK Biobank (a health data bank).
They found that women with endometriosis (a pathology caused by the growth of tissue that resembles the lining of the uterus in other parts of the body) were twice as likely to be diagnosed with disorders of the gastrointestinal tract, in particular, intestinal diseases.
| Photo: belchonock/Depositphotos |
They also identified specific regions of the genome that contain key gene variants associated with both endometriosis and each of the gastrointestinal diseases.
The scientists analyzed a number of studies by their colleagues and found patterns in the genetic correlation between endometriosis, PCOS, gastroesophageal reflux disease (GERD), and peptic ulcers. The last two were grouped together, because they are caused by high acidity in the stomach and have similar treatment.
Genes associated with a higher risk of developing both PCOS and endometriosis were found in three regions of the genome and included, for example, the gene MYSM1, which plays a role in immune function.
Genes associated with stomach acidity and endometriosis were spread across six DNA regions and included the RERG gene, which is regulated by the hormone estrogen.
Another four regions of the genome were potentially associated with endometriosis, PCOS and acidity in the stomach.
However, Sally Mortlock, a researcher and researcher at the University of Queensland in Australia, noted that the study had several limitations.
For example, only the common pathology of endometriosis was considered, but there are different subtypes of the disease that can predispose people to various gastrointestinal disorders.
Also, diseases were studied only at the molecular level, and not comprehensively.
Read also: 7 non-obvious symptoms that should not be ignored
[ad_2]
Original Source Link
