Scientists discovered that the cells of the skull interact with the membranes of the brain: how useful is this discovery
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Scientists have discovered a connection between the bone marrow and the outer shell of the brain. This discovery will help in the diagnosis and treatment of Alzheimer’s disease and multiple sclerosis, writes Science Alert with reference to the results of research by a group of scientists from Germany and Great Britain in the journal Cell. A research team from Germany and the UK has discovered pathways from the skull’s bone marrow through the outer surface of the brain’s protective membranes that keep immune cells moving but also make it difficult to access the brain for treatment during inflammation. “This opens up many possibilities for the diagnosis and treatment of brain diseases and could revolutionize our understanding of neurological diseases. This breakthrough could lead to more effective monitoring of conditions such as Alzheimer’s disease and stroke, and potentially even help prevent these diseases through early detection.” – believes neurobiologist Ali Erturk from the University of Munich in Germany. Brain signals. Photo: Kolabas et al., Cell Immune cells can enter the brain after a number of diseases, such as a stroke, which causes a weakening of the blood-brain barrier (a physiological mechanism that protects the human brain from viruses, bacteria from the blood). Scientists investigated the cellular architecture of the connections between the skull and the meninges. It turned out that they extend closer to the surface of the brain than scientists previously thought. Often they penetrate the outer and strongest shell of the brain. Interactions between skull cells and brain membranes “These findings have profound implications, suggesting a much more complex connection between the skull and the brain than previously thought,” said Ilgin Kolabas, a neuroimmunologist at the University of Munich. In total, the scientists examined cells from six different bones, the dura mater and the brain. They found that different bones have different molecular profiles with unique immune cells. In addition, specialized neutrophil cells were found in the cells of the skull – this is a type of leukocytes that play a decisive role in the body’s immune defense. The team of scientists also examined the brains of patients with Alzheimer’s disease and stroke using positron emission tomography. They saw changes in skull signals and increased disease-specific translocator protein signals in different parts of the skull in many neurological diseases. Scientists believe that new discoveries about the skull’s immune response can help diagnose and treat patients with a variety of neurological disorders, such as Alzheimer’s disease, stroke, multiple sclerosis, and more. It will be recalled that scientists previously found a connection between the development of Alzheimer’s and Parkinson’s diseases and viral diseases. Read also: Espresso can help prevent Alzheimer’s disease – scientists
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