Lung damage in asthma: scientists have discovered a new cause
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Scientists in Great Britain have discovered previously unknown damage to the body from asthma
Research by British scientists has shown previously unknown damage to the body from asthma.
They inform about it BBC and Medical Xpress with a reference to a scientific journal Science.
Asthma is an inflammatory disease that is diagnosed by the presence of mechanical compression of small airways. It causes coughing, wheezing, shortness of breath, and chest tightness.
In the course of their research, scientists observed tissue samples from mice and humans. They found that the accumulation of cells during an asthma attack provokes additional inflammation, mucus secretion and, as a result, damage to the airways. The harm is in the emergence of long-term wounds, infections, which cause even more attacks.
To detect side effects, researchers observed tissue samples from mice and humans.
Scientists have found that the use of a common emergency aid – albuterol (common in the form of a powder inhaler) – although it helps to relax the airways, it does not prevent additional damage.
They suggest that blocking the new damage mechanism may prevent the disease cycle.
“If we can block the damage, hopefully that can stop the attacks altogether.”– explained the potential of the discovery, the lead researcher, Professor Jody Rosenblatt.
Scientists have also successfully tested gadolinium as one of the preventive treatment methods.
“Fortunately, we found that we could use an inexpensive gadolinium compound often used in MRI to stop the damage to the airways in mice, as well as the subsequent inflammation and mucus secretion,” – scientists note.
The authors note that gadolinium has not been tested in humans and is not yet considered safe or effective.
“This opens important new avenues for exploring possible new treatment options that are desperately needed for people with asthma.” says director of research and innovation at the British charity Asthma and Lung UK, Samantha Walker.
According to estimates of the comprehensive research program Global Burden of Disease collaboration, asthma affects 262 million people worldwide. As are reported in the global report summarizing research on asthma, The Global Asthma Report 2022, the disease claims more than a thousand lives every day.
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Anna Kovalenko, “UP. Life”
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